diff --git a/README.md b/README.md
index acea710..0f69d7f 100644
--- a/README.md
+++ b/README.md
@@ -165,3 +165,22 @@ This automatically configures your CI environment to use Aikido Safe Chain for a
 ```
 
 After setup, all subsequent package manager commands in your CI pipeline will automatically be protected by Aikido Safe Chain's malware detection.
+
+### Python (pip/pip3) example
+
+```yaml
+- name: Setup Python
+  uses: actions/setup-python@v5
+  with:
+    python-version: '3.x'
+
+- name: Setup safe-chain
+  run: |
+    npm i -g @aikidosec/safe-chain
+    safe-chain setup-ci
+
+- name: Install Python dependencies
+  run: |
+    pip3 install --upgrade pip
+    pip3 install -r requirements.txt
+```
diff --git a/packages/safe-chain/src/shell-integration/path-wrappers/templates/unix-python-wrapper.template.sh b/packages/safe-chain/src/shell-integration/path-wrappers/templates/unix-python-wrapper.template.sh
new file mode 100644
index 0000000..c4edf2a
--- /dev/null
+++ b/packages/safe-chain/src/shell-integration/path-wrappers/templates/unix-python-wrapper.template.sh
@@ -0,0 +1,31 @@
+#!/bin/sh
+# Generated wrapper for python/python3 by safe-chain
+# Intercepts `python[3] -m pip[...]` in CI environments
+
+# Function to remove shim from PATH (POSIX-compliant)
+remove_shim_from_path() {
+    echo "$PATH" | sed "s|$HOME/.safe-chain/shims:||g"
+}
+
+# Determine which python variant we were invoked as based on the script name
+invoked=$(basename "$0")
+
+# If invoked as `python -m pip[...]` or `python3 -m pip[...]`, route to aikido
+if [ "$1" = "-m" ] && [ -n "$2" ] && echo "$2" | grep -Eq '^pip(3)?$'; then
+  mod="$2"
+  shift 2
+  if [ "$invoked" = "python3" ] || [ "$mod" = "pip3" ]; then
+    PATH=$(remove_shim_from_path) exec aikido-pip3 "$@"
+  else
+    PATH=$(remove_shim_from_path) exec aikido-pip "$@"
+  fi
+fi
+
+# Otherwise, find and exec the real python/python3 matching the invoked name
+original_cmd=$(PATH=$(remove_shim_from_path) command -v "$invoked")
+if [ -n "$original_cmd" ]; then
+  exec "$original_cmd" "$@"
+else
+  echo "Error: Could not find original $invoked" >&2
+  exit 1
+fi
diff --git a/packages/safe-chain/src/shell-integration/path-wrappers/templates/windows-python-wrapper.template.cmd b/packages/safe-chain/src/shell-integration/path-wrappers/templates/windows-python-wrapper.template.cmd
new file mode 100644
index 0000000..c9f1eda
--- /dev/null
+++ b/packages/safe-chain/src/shell-integration/path-wrappers/templates/windows-python-wrapper.template.cmd
@@ -0,0 +1,39 @@
+@echo off
+REM Generated wrapper for python/python3 by safe-chain
+REM Intercepts `python[3] -m pip[...]` in CI environments
+
+REM Remove shim directory from PATH to prevent infinite loops
+set "SHIM_DIR=%USERPROFILE%\.safe-chain\shims"
+call set "CLEAN_PATH=%%PATH:%SHIM_DIR%;=%%"
+
+REM Determine invoked name (python or python3) from the script name
+set "INVOKED=%~n0"
+
+REM Check for -m pip or -m pip3
+if "%1"=="-m" (
+  if /I "%2"=="pip3" (
+    shift
+    shift
+    set "PATH=%CLEAN_PATH%" & aikido-pip3 %*
+    goto :eof
+  )
+  if /I "%2"=="pip" (
+    shift
+    shift
+    if /I "%INVOKED%"=="python3" (
+      set "PATH=%CLEAN_PATH%" & aikido-pip3 %*
+    ) else (
+      set "PATH=%CLEAN_PATH%" & aikido-pip %*
+    )
+    goto :eof
+  )
+)
+
+REM Fallback to real python/python3 matching the invoked name
+for /f "tokens=*" %%i in ('set "PATH=%CLEAN_PATH%" ^& where %INVOKED% 2^>nul') do (
+  "%%i" %*
+  goto :eof
+)
+
+echo Error: Could not find original %INVOKED% 1>&2
+exit /b 1
diff --git a/packages/safe-chain/src/shell-integration/setup-ci.js b/packages/safe-chain/src/shell-integration/setup-ci.js
index 64fff16..b061bb6 100644
--- a/packages/safe-chain/src/shell-integration/setup-ci.js
+++ b/packages/safe-chain/src/shell-integration/setup-ci.js
@@ -51,13 +51,9 @@ function createUnixShims(shimsDir) {
 
   const template = fs.readFileSync(templatePath, "utf-8");
 
-  // Create a shim for each tool except pip (CI support not yet implemented)
+  // Create a shim for each tool
   let created = 0;
   for (const toolInfo of knownAikidoTools) {
-    if (toolInfo.tool === "pip") {
-      continue; // Skip pip shims in CI for now
-    }
-
     const shimContent = template
       .replaceAll("{{PACKAGE_MANAGER}}", toolInfo.tool)
       .replaceAll("{{AIKIDO_COMMAND}}", toolInfo.aikidoCommand);
@@ -70,11 +66,54 @@ function createUnixShims(shimsDir) {
     created++;
   }
 
+  // Also create python and python3 shims to support `python[3] -m pip[3]` in CI
+  createUnixPythonShims(shimsDir);
+
   ui.writeInformation(
     `Created ${created} Unix shim(s) in ${shimsDir}`
   );
 }
 
+/**
+ * @param {string} shimsDir
+ */
+function createUnixPythonShims(shimsDir) {
+  const __filename = fileURLToPath(import.meta.url);
+  const __dirname = path.dirname(__filename);
+
+  const entries = [
+    {
+      name: "python",
+      template: path.resolve(
+        __dirname,
+        "path-wrappers",
+        "templates",
+        "unix-python-wrapper.template.sh"
+      ),
+    },
+    {
+      name: "python3",
+      template: path.resolve(
+        __dirname,
+        "path-wrappers",
+        "templates",
+        "unix-python-wrapper.template.sh"
+      ),
+    },
+  ];
+
+  for (const entry of entries) {
+    if (!fs.existsSync(entry.template)) {
+      ui.writeError(`Template file not found: ${entry.template}`);
+      continue;
+    }
+    const shimContent = fs.readFileSync(entry.template, "utf-8");
+  const shimPath = `${shimsDir}/${entry.name}`;
+    fs.writeFileSync(shimPath, shimContent, "utf-8");
+    fs.chmodSync(shimPath, 0o755);
+  }
+}
+
 /**
  * @param {string} shimsDir
  *
@@ -98,27 +137,65 @@ function createWindowsShims(shimsDir) {
 
   const template = fs.readFileSync(templatePath, "utf-8");
 
-  // Create a shim for each tool except pip (CI support not yet implemented)
+  // Create a shim for each tool
   let created = 0;
   for (const toolInfo of knownAikidoTools) {
-    if (toolInfo.tool === "pip") {
-      continue; // Skip pip shims in CI for now
-    }
-
     const shimContent = template
       .replaceAll("{{PACKAGE_MANAGER}}", toolInfo.tool)
       .replaceAll("{{AIKIDO_COMMAND}}", toolInfo.aikidoCommand);
 
-    const shimPath = path.join(shimsDir, `${toolInfo.tool}.cmd`);
+  const shimPath = `${shimsDir}/${toolInfo.tool}.cmd`;
     fs.writeFileSync(shimPath, shimContent, "utf-8");
     created++;
   }
 
+  // Also create python and python3 shims for Windows to support `python[3] -m pip[3]` in CI
+  createWindowsPythonShims(shimsDir);
+
   ui.writeInformation(
     `Created ${created} Windows shim(s) in ${shimsDir}`
   );
 }
 
+/**
+ * @param {string} shimsDir
+ */
+function createWindowsPythonShims(shimsDir) {
+  const __filename = fileURLToPath(import.meta.url);
+  const __dirname = path.dirname(__filename);
+
+  const entries = [
+    {
+      name: "python.cmd",
+      template: path.resolve(
+        __dirname,
+        "path-wrappers",
+        "templates",
+        "windows-python-wrapper.template.cmd"
+      ),
+    },
+    {
+      name: "python3.cmd",
+      template: path.resolve(
+        __dirname,
+        "path-wrappers",
+        "templates",
+        "windows-python-wrapper.template.cmd"
+      ),
+    },
+  ];
+
+  for (const entry of entries) {
+    if (!fs.existsSync(entry.template)) {
+      ui.writeError(`Windows template file not found: ${entry.template}`);
+      continue;
+    }
+    const shimContent = fs.readFileSync(entry.template, "utf-8");
+  const shimPath = `${shimsDir}/${entry.name}`;
+    fs.writeFileSync(shimPath, shimContent, "utf-8");
+  }
+}
+
 /**
  * @param {string} shimsDir
  *
diff --git a/test/e2e/pip-ci.e2e.spec.js b/test/e2e/pip-ci.e2e.spec.js
new file mode 100644
index 0000000..7b2bfa0
--- /dev/null
+++ b/test/e2e/pip-ci.e2e.spec.js
@@ -0,0 +1,139 @@
+import { describe, it, before, beforeEach, afterEach } from "node:test";
+import { DockerTestContainer } from "./DockerTestContainer.js";
+import assert from "node:assert";
+
+describe("E2E: safe-chain setup-ci command for pip/pip3", () => {
+  let container;
+
+  before(async () => {
+    DockerTestContainer.buildImage();
+  });
+
+  beforeEach(async () => {
+    container = new DockerTestContainer();
+    await container.start();
+  });
+
+  afterEach(async () => {
+    if (container) {
+      await container.stop();
+      container = null;
+    }
+  });
+
+  for (let shell of ["bash", "zsh"]) {
+    it(`safe-chain setup-ci wraps pip3 command with PATH shim after installation for ${shell}`, async () => {
+      // Setup safe-chain CI shims
+      const installationShell = await container.openShell(shell);
+      await installationShell.runCommand("safe-chain setup-ci");
+
+      // Add $HOME/.safe-chain/shims to PATH for subsequent shells
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.zshrc"
+      );
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.bashrc"
+      );
+
+      const projectShell = await container.openShell(shell);
+      // Use --break-system-packages to avoid Debian/Ubuntu external management restrictions
+      const result = await projectShell.runCommand(
+        "pip3 install --break-system-packages certifi"
+      );
+
+      const hasExpectedOutput = result.output.includes(
+        "Scanning for malicious packages..."
+      );
+      assert.ok(
+        hasExpectedOutput,
+        hasExpectedOutput
+          ? "Expected pip3 command to be wrapped by safe-chain"
+          : `Output did not contain \"Scanning for malicious packages...\": \n${result.output}`
+      );
+    });
+
+    it(`setup-ci routes python -m pip through safe-chain for ${shell}`, async () => {
+      const installationShell = await container.openShell(shell);
+      await installationShell.runCommand("safe-chain setup-ci");
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.zshrc"
+      );
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.bashrc"
+      );
+
+      const projectShell = await container.openShell(shell);
+      const result = await projectShell.runCommand(
+        "python -m pip install --break-system-packages certifi"
+      );
+
+      assert.ok(
+        result.output.includes("Scanning for malicious packages..."),
+        `Output did not contain scan message. Output was:\n${result.output}`
+      );
+    });
+
+    it(`setup-ci routes python -m pip3 through safe-chain for ${shell}`, async () => {
+      const installationShell = await container.openShell(shell);
+      await installationShell.runCommand("safe-chain setup-ci");
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.zshrc"
+      );
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.bashrc"
+      );
+
+      const projectShell = await container.openShell(shell);
+      const result = await projectShell.runCommand(
+        "python -m pip3 install --break-system-packages certifi"
+      );
+
+      assert.ok(
+        result.output.includes("Scanning for malicious packages..."),
+        `Output did not contain scan message. Output was:\n${result.output}`
+      );
+    });
+
+    it(`setup-ci routes python3 -m pip through safe-chain for ${shell}`, async () => {
+      const installationShell = await container.openShell(shell);
+      await installationShell.runCommand("safe-chain setup-ci");
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.zshrc"
+      );
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.bashrc"
+      );
+
+      const projectShell = await container.openShell(shell);
+      const result = await projectShell.runCommand(
+        "python3 -m pip install --break-system-packages certifi"
+      );
+
+      assert.ok(
+        result.output.includes("Scanning for malicious packages..."),
+        `Output did not contain scan message. Output was:\n${result.output}`
+      );
+    });
+
+    it(`setup-ci routes python3 -m pip3 through safe-chain for ${shell}`, async () => {
+      const installationShell = await container.openShell(shell);
+      await installationShell.runCommand("safe-chain setup-ci");
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.zshrc"
+      );
+      await installationShell.runCommand(
+        "echo 'export PATH=\"$HOME/.safe-chain/shims:$PATH\"' >> ~/.bashrc"
+      );
+
+      const projectShell = await container.openShell(shell);
+      const result = await projectShell.runCommand(
+        "python3 -m pip3 install --break-system-packages certifi"
+      );
+
+      assert.ok(
+        result.output.includes("Scanning for malicious packages..."),
+        `Output did not contain scan message. Output was:\n${result.output}`
+      );
+    });
+  }
+});