diff --git a/README.md b/README.md
index 3e73137..1bc4858 100644
--- a/README.md
+++ b/README.md
@@ -23,6 +23,7 @@ Aikido Safe Chain supports the following package managers:
 - 📦 **pip3**
 - 📦 **uv**
 - 📦 **poetry**
+- 📦 **uvx**
 - 📦 **pipx**
 
 # Usage
@@ -66,7 +67,7 @@ You can find all available versions on the [releases page](https://github.com/Ai
 ### Verify the installation
 
 1. **❗Restart your terminal** to start using the Aikido Safe Chain.
-   - This step is crucial as it ensures that the shell aliases for npm, npx, yarn, pnpm, pnpx, bun, bunx, pip, pip3, poetry, uv and pipx are loaded correctly. If you do not restart your terminal, the aliases will not be available.
+   - This step is crucial as it ensures that the shell aliases for npm, npx, yarn, pnpm, pnpx, bun, bunx, pip, pip3, poetry, uv, uvx and pipx are loaded correctly. If you do not restart your terminal, the aliases will not be available.
 
 2. **Verify the installation** by running the verification command:
 
@@ -97,7 +98,7 @@ You can find all available versions on the [releases page](https://github.com/Ai
 
    - The output should show that Aikido Safe Chain is blocking the installation of these test packages as they are flagged as malware.
 
-When running `npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `poetry` and `pipx` commands, the Aikido Safe Chain will automatically check for malware in the packages you are trying to install. It also intercepts Python module invocations for pip when available (e.g., `python -m pip install ...`, `python3 -m pip download ...`). If any malware is detected, it will prompt you to exit the command.
+When running `npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `uvx`, `poetry` and `pipx` commands, the Aikido Safe Chain will automatically check for malware in the packages you are trying to install. It also intercepts Python module invocations for pip when available (e.g., `python -m pip install ...`, `python3 -m pip download ...`). If any malware is detected, it will prompt you to exit the command.
 
 You can check the installed version by running:
 
@@ -109,7 +110,7 @@ safe-chain --version
 
 ### Malware Blocking
 
-The Aikido Safe Chain works by running a lightweight proxy server that intercepts package downloads from the npm registry and PyPI. When you run npm, npx, yarn, pnpm, pnpx, bun, bunx, pip, pip3, uv, poetry or pipx commands, all package downloads are routed through this local proxy, which verifies packages in real-time against **[Aikido Intel - Open Sources Threat Intelligence](https://intel.aikido.dev/?tab=malware)**. If malware is detected in any package (including deep dependencies), the proxy blocks the download before the malicious code reaches your machine.
+The Aikido Safe Chain works by running a lightweight proxy server that intercepts package downloads from the npm registry and PyPI. When you run npm, npx, yarn, pnpm, pnpx, bun, bunx, pip, pip3, uv, uvx, poetry or pipx commands, all package downloads are routed through this local proxy, which verifies packages in real-time against **[Aikido Intel - Open Sources Threat Intelligence](https://intel.aikido.dev/?tab=malware)**. If malware is detected in any package (including deep dependencies), the proxy blocks the download before the malicious code reaches your machine.
 
 ### Minimum package age
 
@@ -128,7 +129,7 @@ By default, the minimum package age is 48 hours. This provides an additional sec
 
 ### Shell Integration
 
-The Aikido Safe Chain integrates with your shell to provide a seamless experience when using npm, npx, yarn, pnpm, pnpx, bun, bunx, and Python package managers (pip, uv, poetry, pipx). It sets up aliases for these commands so that they are wrapped by the Aikido Safe Chain commands, which manage the proxy server before executing the original commands. We currently support:
+The Aikido Safe Chain integrates with your shell to provide a seamless experience when using npm, npx, yarn, pnpm, pnpx, bun, bunx, and Python package managers (pip, uv, uvx, poetry, pipx). It sets up aliases for these commands so that they are wrapped by the Aikido Safe Chain commands, which manage the proxy server before executing the original commands. We currently support:
 
 - ✅ **Bash**
 - ✅ **Zsh**
diff --git a/docs/shell-integration.md b/docs/shell-integration.md
index 6b08fac..2e36d0a 100644
--- a/docs/shell-integration.md
+++ b/docs/shell-integration.md
@@ -2,7 +2,7 @@
 
 ## Overview
 
-The shell integration automatically wraps common package manager commands (`npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `poetry`, `pipx`) with Aikido's security scanning functionality. It also intercepts Python module invocations for pip when available: `python -m pip`, `python -m pip3`, `python3 -m pip`, `python3 -m pip3`. This is achieved by sourcing startup scripts that define shell functions to wrap these commands with their Aikido-protected equivalents.
+The shell integration automatically wraps common package manager commands (`npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `uvx`, `poetry`, `pipx`) with Aikido's security scanning functionality. It also intercepts Python module invocations for pip when available: `python -m pip`, `python -m pip3`, `python3 -m pip`, `python3 -m pip3`. This is achieved by sourcing startup scripts that define shell functions to wrap these commands with their Aikido-protected equivalents.
 
 ## Supported Shells
 
@@ -28,7 +28,7 @@ This command:
 
 - Copies necessary startup scripts to Safe Chain's installation directory (`~/.safe-chain/scripts`)
 - Detects all supported shells on your system
-- Sources each shell's startup file to add Safe Chain functions for `npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `poetry` and `pipx`
+- Sources each shell's startup file to add Safe Chain functions for `npm`, `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `uvx`, `poetry` and `pipx`
 - Adds lightweight interceptors so `python -m pip[...]` and `python3 -m pip[...]` route through Safe Chain when invoked by name
 
 ❗ After running this command, **you must restart your terminal** for the changes to take effect. This ensures that the startup scripts are sourced correctly.
@@ -78,7 +78,7 @@ The system modifies the following files to source Safe Chain startup scripts:
 This means the shell functions are working but the Aikido commands aren't installed or available in your PATH:
 
 - Make sure Aikido Safe Chain is properly installed on your system
-- Verify the `aikido-npm`, `aikido-npx`, `aikido-yarn`, `aikido-pnpm`, `aikido-pnpx`, `aikido-bun`, `aikido-bunx`, `aikido-pip`, `aikido-pip3`, `aikido-uv`, `aikido-poetry` and `aikido-pipx` commands exist
+- Verify the `aikido-npm`, `aikido-npx`, `aikido-yarn`, `aikido-pnpm`, `aikido-pnpx`, `aikido-bun`, `aikido-bunx`, `aikido-pip`, `aikido-pip3`, `aikido-uv`, `aikido-uvx`, `aikido-poetry` and `aikido-pipx` commands exist
 - Check that these commands are in your system's PATH
 
 ### Manual Verification
@@ -121,7 +121,7 @@ npm() {
 }
 ```
 
-Repeat this pattern for `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `poetry` and `pipx` using their respective `aikido-*` commands. After adding these functions, restart your terminal to apply the changes.
+Repeat this pattern for `npx`, `yarn`, `pnpm`, `pnpx`, `bun`, `bunx`, `pip`, `pip3`, `uv`, `uvx`, `poetry` and `pipx` using their respective `aikido-*` commands. After adding these functions, restart your terminal to apply the changes.
 
 To intercept Python module invocations for pip without altering Python itself, you can add small forwarding functions:
 
diff --git a/npm-shrinkwrap.json b/npm-shrinkwrap.json
index c852d4f..9b8fc33 100644
--- a/npm-shrinkwrap.json
+++ b/npm-shrinkwrap.json
@@ -2417,6 +2417,7 @@
       "integrity": "sha512-5gTmgEY/sqK6gFXLIsQNH19lWb4ebPDLA4SdLP7dsWkIXHWlG66oPuVvXSGFPppYZz8ZDZq0dYYrbHfBCVUb1Q==",
       "dev": true,
       "license": "MIT",
+      "peer": true,
       "engines": {
         "node": ">=12"
       },
@@ -3138,6 +3139,7 @@
         "aikido-python": "bin/aikido-python.js",
         "aikido-python3": "bin/aikido-python3.js",
         "aikido-uv": "bin/aikido-uv.js",
+        "aikido-uvx": "bin/aikido-uvx.js",
         "aikido-yarn": "bin/aikido-yarn.js",
         "safe-chain": "bin/safe-chain.js"
       },
diff --git a/packages/safe-chain/bin/aikido-uvx.js b/packages/safe-chain/bin/aikido-uvx.js
new file mode 100755
index 0000000..10bb9f3
--- /dev/null
+++ b/packages/safe-chain/bin/aikido-uvx.js
@@ -0,0 +1,16 @@
+#!/usr/bin/env node
+
+import { main } from "../src/main.js";
+import { initializePackageManager } from "../src/packagemanager/currentPackageManager.js";
+import { setEcoSystem, ECOSYSTEM_PY } from "../src/config/settings.js";
+
+// Set eco system
+setEcoSystem(ECOSYSTEM_PY);
+
+initializePackageManager("uvx");
+
+(async () => {
+  // Pass through only user-supplied uvx args
+  var exitCode = await main(process.argv.slice(2));
+  process.exit(exitCode);
+})();
diff --git a/packages/safe-chain/package.json b/packages/safe-chain/package.json
index 3d527cb..8530b68 100644
--- a/packages/safe-chain/package.json
+++ b/packages/safe-chain/package.json
@@ -16,6 +16,7 @@
     "aikido-bun": "bin/aikido-bun.js",
     "aikido-bunx": "bin/aikido-bunx.js",
     "aikido-uv": "bin/aikido-uv.js",
+    "aikido-uvx": "bin/aikido-uvx.js",
     "aikido-pip": "bin/aikido-pip.js",
     "aikido-pip3": "bin/aikido-pip3.js",
     "aikido-python": "bin/aikido-python.js",
@@ -36,7 +37,7 @@
   "keywords": [],
   "author": "Aikido Security",
   "license": "AGPL-3.0-or-later",
-  "description": "The Aikido Safe Chain wraps around the [npm cli](https://github.com/npm/cli), [npx](https://github.com/npm/cli/blob/latest/docs/content/commands/npx.md), [yarn](https://yarnpkg.com/), [pnpm](https://pnpm.io/), [pnpx](https://pnpm.io/cli/dlx), [bun](https://bun.sh/), [bunx](https://bun.sh/docs/cli/bunx), [uv](https://docs.astral.sh/uv/) (Python), and [pip](https://pip.pypa.io/) to provide extra checks before installing new packages. This tool will detect when a package contains malware and prompt you to exit, preventing npm, npx, yarn, pnpm, pnpx, bun, bunx, uv, or pip/pip3 from downloading or running the malware.",
+  "description": "The Aikido Safe Chain wraps around the [npm cli](https://github.com/npm/cli), [npx](https://github.com/npm/cli/blob/latest/docs/content/commands/npx.md), [yarn](https://yarnpkg.com/), [pnpm](https://pnpm.io/), [pnpx](https://pnpm.io/cli/dlx), [bun](https://bun.sh/), [bunx](https://bun.sh/docs/cli/bunx), [uv](https://docs.astral.sh/uv/) (Python), and [pip](https://pip.pypa.io/) to provide extra checks before installing new packages. This tool will detect when a package contains malware and prompt you to exit, preventing npm, npx, yarn, pnpm, pnpx, bun, bunx, uv, uvx, or pip/pip3 from downloading or running the malware.",
   "dependencies": {
     "certifi": "14.5.15",
     "chalk": "5.4.1",
diff --git a/packages/safe-chain/src/packagemanager/currentPackageManager.js b/packages/safe-chain/src/packagemanager/currentPackageManager.js
index af297dc..2291fd1 100644
--- a/packages/safe-chain/src/packagemanager/currentPackageManager.js
+++ b/packages/safe-chain/src/packagemanager/currentPackageManager.js
@@ -13,6 +13,7 @@ import { createPipPackageManager } from "./pip/createPackageManager.js";
 import { createUvPackageManager } from "./uv/createUvPackageManager.js";
 import { createPoetryPackageManager } from "./poetry/createPoetryPackageManager.js";
 import { createPipXPackageManager } from "./pipx/createPipXPackageManager.js";
+import { createUvxPackageManager } from "./uvx/createUvxPackageManager.js";
 
 /**
  * @type {{packageManagerName: PackageManager | null}}
@@ -60,6 +61,8 @@ export function initializePackageManager(packageManagerName, context) {
     state.packageManagerName = createPipPackageManager(context);
   } else if (packageManagerName === "uv") {
     state.packageManagerName = createUvPackageManager();
+  } else if (packageManagerName === "uvx") {
+    state.packageManagerName = createUvxPackageManager();
   } else if (packageManagerName === "poetry") {
     state.packageManagerName = createPoetryPackageManager();
   } else if (packageManagerName === "pipx") {
diff --git a/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.js b/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.js
new file mode 100644
index 0000000..18a7089
--- /dev/null
+++ b/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.js
@@ -0,0 +1,18 @@
+import { runUv } from "../uv/runUvCommand.js";
+
+/**
+ * @returns {import("../currentPackageManager.js").PackageManager}
+ */
+export function createUvxPackageManager() {
+  return {
+    /**
+     * @param {string[]} args
+     */
+    runCommand: (args) => {
+      return runUv("uvx", args);
+    },
+    // For uvx, rely solely on MITM
+    isSupportedCommand: () => false,
+    getDependencyUpdatesForCommand: () => [],
+  };
+}
diff --git a/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.spec.js b/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.spec.js
new file mode 100644
index 0000000..6eb87a0
--- /dev/null
+++ b/packages/safe-chain/src/packagemanager/uvx/createUvxPackageManager.spec.js
@@ -0,0 +1,14 @@
+import { test } from "node:test";
+import assert from "node:assert";
+import { createUvxPackageManager } from "./createUvxPackageManager.js";
+
+test("createUvxPackageManager returns valid package manager interface", () => {
+  const pm = createUvxPackageManager();
+
+  assert.ok(pm);
+  assert.strictEqual(typeof pm.runCommand, "function");
+  assert.strictEqual(typeof pm.isSupportedCommand, "function");
+  assert.strictEqual(typeof pm.getDependencyUpdatesForCommand, "function");
+  assert.strictEqual(pm.isSupportedCommand(), false);
+  assert.deepStrictEqual(pm.getDependencyUpdatesForCommand(), []);
+});
diff --git a/packages/safe-chain/src/shell-integration/helpers.js b/packages/safe-chain/src/shell-integration/helpers.js
index 18ba52e..dd86462 100644
--- a/packages/safe-chain/src/shell-integration/helpers.js
+++ b/packages/safe-chain/src/shell-integration/helpers.js
@@ -66,6 +66,12 @@ export const knownAikidoTools = [
     ecoSystem: ECOSYSTEM_PY,
     internalPackageManagerName: "uv",
   },
+  {
+    tool: "uvx",
+    aikidoCommand: "aikido-uvx",
+    ecoSystem: ECOSYSTEM_PY,
+    internalPackageManagerName: "uvx",
+  },
   {
     tool: "pip",
     aikidoCommand: "aikido-pip",
diff --git a/packages/safe-chain/src/shell-integration/startup-scripts/init-fish.fish b/packages/safe-chain/src/shell-integration/startup-scripts/init-fish.fish
index 13463f6..fdb501f 100644
--- a/packages/safe-chain/src/shell-integration/startup-scripts/init-fish.fish
+++ b/packages/safe-chain/src/shell-integration/startup-scripts/init-fish.fish
@@ -51,6 +51,10 @@ function uv
     wrapSafeChainCommand "uv" $argv
 end
 
+function uvx
+    wrapSafeChainCommand "uvx" $argv
+end
+
 function poetry
     wrapSafeChainCommand "poetry" $argv
 end
diff --git a/packages/safe-chain/src/shell-integration/startup-scripts/init-posix.sh b/packages/safe-chain/src/shell-integration/startup-scripts/init-posix.sh
index ebaaf3c..ea09ef0 100644
--- a/packages/safe-chain/src/shell-integration/startup-scripts/init-posix.sh
+++ b/packages/safe-chain/src/shell-integration/startup-scripts/init-posix.sh
@@ -47,6 +47,10 @@ function uv() {
   wrapSafeChainCommand "uv" "$@"
 }
 
+function uvx() {
+  wrapSafeChainCommand "uvx" "$@"
+}
+
 function poetry() {
   wrapSafeChainCommand "poetry" "$@"
 }
diff --git a/packages/safe-chain/src/shell-integration/startup-scripts/init-pwsh.ps1 b/packages/safe-chain/src/shell-integration/startup-scripts/init-pwsh.ps1
index f82d0fc..4cdefee 100644
--- a/packages/safe-chain/src/shell-integration/startup-scripts/init-pwsh.ps1
+++ b/packages/safe-chain/src/shell-integration/startup-scripts/init-pwsh.ps1
@@ -52,6 +52,10 @@ function uv {
     Invoke-WrappedCommand "uv" $args $MyInvocation.Line $MyInvocation.OffsetInLine
 }
 
+function uvx {
+    Invoke-WrappedCommand "uvx" $args $MyInvocation.Line $MyInvocation.OffsetInLine
+}
+
 function poetry {
     Invoke-WrappedCommand "poetry" $args $MyInvocation.Line $MyInvocation.OffsetInLine
 }